|
|
H2O + acetoacetyl-CoA <=> H+ + acetoacetate + CoA
|
3.1.2.1
acetyl-CoA hydrolase
3.1.2.11
acetoacetyl-CoA hydrolase
3.1.2.18
ADP-dependent short-chain-acyl-CoA hydrolase
3.1.2.32
2-aminobenzoylacetyl-CoA thioesterase
|
–
–
–
–
|
MK
|
|
BRENDA:
BR10671
KEGG:
R01358
MetaCyc:
ACETOACETYL-COA-HYDROLASE-RXN
|
|
|
|
(S)-3-hydroxybutyryl-CoA + NADP+ <=> acetoacetyl-CoA + NADPH + H+
|
1.1.1.157
3-hydroxybutyryl-CoA dehydrogenase
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
|
–
–
|
K
|
|
BRENDA:
BR29222;
BS429714
KEGG:
R01976
MetaCyc:
3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN
SABIO-RK:
2019
|
|
|
|
acetyl-CoA <=> acetoacetyl-CoA + CoA
|
1.1.1.34
hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155
acetyl-CoA C-myristoyltransferase
2.3.1.16
acetyl-CoA C-acyltransferase
2.3.1.38
[acyl-carrier-protein] S-acetyltransferase
2.3.1.9
acetyl-CoA C-acetyltransferase
|
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR44092
KEGG:
R00238
MetaCyc:
ACETYL-COA-ACETYLTRANSFER-RXN
SABIO-RK:
531
|
|
|
|
acetoacetyl-CoA + H2O + acetyl-CoA <=> H+ + CoA + (S)-3-hydroxy-3-methylglutaryl-CoA
|
2.3.3.10
hydroxymethylglutaryl-CoA synthase
|
–
|
BMK
|
|
BRENDA:
BR44119
KEGG:
R01978
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN
SABIO-RK:
2021
|
|
|
|
butyryl-CoA + acetoacetate <=> Butyrate + acetoacetyl-CoA
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
MK
|
|
BRENDA:
BR47924
KEGG:
R01365
MetaCyc:
2.8.3.9-RXN
SABIO-RK:
1567
|
|
|
|
acetyl-CoA + malonyl-CoA + H+ <=> acetoacetyl-CoA + CoA + CO2
|
2.3.1.194
acetoacetyl-CoA synthase
|
–
|
|
|
BRENDA:
BR49309
KEGG:
R09527
MetaCyc:
RXN-11497
|
|
|
|
DL-3-aminobutyryl-CoA + 2-oxoglutarate <=> acetoacetyl-CoA + L-glutamate
|
2.6.1.111
3-aminobutanoyl-CoA transaminase
|
–
|
|
|
BRENDA:
BR51974
KEGG:
R11607
MetaCyc:
RXN-18379
|
|
|
|
ATP + L-isoleucine + acetoacetyl-CoA <=> AMP + diphosphate + tenuazonic_acid + CoA + H+
|
6.3.2.50
tenuazonic acid synthetase
|
–
|
|
|
BRENDA:
BR52071
KEGG:
R11723
MetaCyc:
RXN-18314
|
|
|
|
CoA + acetoacetate + ATP <=> acetoacetyl-CoA + diphosphate + AMP
|
6.2.1.16
acetoacetate---CoA ligase
|
–
|
MK
|
|
BRENDA:
BR67
KEGG:
R01357
MetaCyc:
ACETOACETATE--COA-LIGASE-RXN
SABIO-RK:
1561
|
|
|
|
(S)-3-hydroxybutyryl-CoA + NAD+ <=> acetoacetyl-CoA + NADH + H+
|
1.1.1.178
3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
1.1.1.36
acetoacetyl-CoA reductase
|
–
–
–
|
BMK
|
|
BRENDA:
BS188053
KEGG:
R01975
MetaCyc:
RXN-11662
SABIO-RK:
2018
|
|
|
|
(3R)-hydroxybutyryl-CoA + NADP+ <=> acetoacetyl-CoA + NADPH + H+
|
1.1.1.100
3-oxoacyl-[acyl-carrier-protein] reductase
1.1.1.157
3-hydroxybutyryl-CoA dehydrogenase
1.1.1.36
acetoacetyl-CoA reductase
|
–
–
–
|
BMK
|
|
BRENDA:
BS188074;
BS383049
KEGG:
R01977;
R05576
MetaCyc:
RXN-5901
SABIO-RK:
5178
|
|
|
|
acetyl-CoA + acetoacetate <=> acetate + acetoacetyl-CoA
|
2.8.3.1
propionate CoA-transferase
2.8.3.18
succinyl-CoA:acetate CoA-transferase
2.8.3.8
acetate CoA-transferase
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
–
–
–
|
BMK
|
|
BRENDA:
BS358821
KEGG:
R01359
MetaCyc:
ACETOACETYL-COA-TRANSFER-RXN
SABIO-RK:
1563
|
|
|
|
succinyl-CoA + acetoacetate <=> succinate + acetoacetyl-CoA
|
2.8.3.18
succinyl-CoA:acetate CoA-transferase
2.8.3.5
3-oxoacid CoA-transferase
|
–
–
|
BMK
|
|
BRENDA:
BS360598
KEGG:
R00410
MetaCyc:
RXNI-2
SABIO-RK:
867
|
|
|
|
Vinylacetate + acetoacetyl-CoA <=> vinylacetyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358824
SABIO-RK:
11106
|
|
|
|
propionate + acetoacetyl-CoA <=> propionyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358825
SABIO-RK:
11107
|
|
|
|
3-Mercaptopropionate + acetoacetyl-CoA <=> 3-mercaptopropionyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358826
SABIO-RK:
11108
|
|
|
|
crotonate + acetoacetyl-CoA <=> crotonyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358827
SABIO-RK:
11109
|
|
|
|
pentanoate + acetoacetyl-CoA <=> pentanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358829
SABIO-RK:
11110
|
|
|
|
Isobutyrate + acetoacetyl-CoA <=> isobutyryl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358830
SABIO-RK:
11111
|
|
|
|
3-Methylvinylacetate + acetoacetyl-CoA <=> 3-methylvinylacetyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358832
SABIO-RK:
11112
|
|
|
|
beta-hydroxybutyrate + acetoacetyl-CoA <=> 3-hydroxybutyryl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358833
SABIO-RK:
11113
|
|
|
|
2-hydroxyvalerate + acetoacetyl-CoA <=> 2-hydroxypentanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358834
SABIO-RK:
11114
|
|
|
|
Isovalerate + acetoacetyl-CoA <=> isovaleryl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358835
SABIO-RK:
11115
|
|
|
|
Acrylate + acetoacetyl-CoA <=> acryloyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358836
SABIO-RK:
11116
|
|
|
|
Chloroacetate + acetoacetyl-CoA <=> chloroacetyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358837
SABIO-RK:
11117
|
|
|
|
4-hydroxybutyrate + acetoacetyl-CoA <=> 4-hydroxybutanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358838
SABIO-RK:
11118
|
|
|
|
3-hydroxypropionate + acetoacetyl-CoA <=> bithionol + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358839
SABIO-RK:
11119
|
|
|
|
DL-2-hydroxybutyrate + acetoacetyl-CoA <=> 2-hydroxybutanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358841
SABIO-RK:
11120
|
|
|
|
DELTA1-piperideine + acetoacetyl-CoA + H2O <=> Pelletierine + CoA + CO2
|
not assigned
|
–
|
K
|
|
KEGG:
R05129
|
|
|
|
[protein]_S-acetyl-L-cysteine + acetyl-CoA <=> acetoacetyl-CoA + protein
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-20155
|
|
|
|
triacetate + acetyl-CoA <=> acetoacetate + acetoacetyl-CoA
|
2.3.1.M84
|
–
|
|
|
MetaCyc:
RXN-20776
|
|
|
|
acetoacetyl-CoA + phosphate <=> Acetoacetylphosphate + CoA
|
2.3.1.19
phosphate butyryltransferase
|
–
|
|
|
BRENDA:
BS320613
|
|
|
|
acetoacetyl-CoA + alpha-D-glucosamine_1-phosphate <=> CoA + N-acetoacetyl-alpha-D-glucosamine_1-phosphate
|
2.3.1.157
glucosamine-1-phosphate N-acetyltransferase
|
–
|
|
|
BRENDA:
BS455152
|
|
|
|
acetoacetyl-CoA + gentamicin <=> CoA + N3''-acetoacetyl-gentamicin
|
2.3.1.60
gentamicin 3-N-acetyltransferase
|
–
|
|
|
BRENDA:
BS408249
|
|
|
|
acetoacetyl-CoA + L-carnitine <=> acetoacetyl-L-carnitine + CoA
|
2.3.1.137
carnitine O-octanoyltransferase
|
–
|
|
|
BRENDA:
BS320453
|
|
|
|
O-acetoacetyl(-)carnitine + CoA <=> acetoacetyl-CoA + L-carnitine
|
2.3.1.7
carnitine O-acetyltransferase
|
–
|
|
|
BRENDA:
BS321223
|
|
|
|
acetoacetyl-CoA + [acyl-carrier_protein] <=> CoA + acetoacetyl-[acyl-carrier_protein]
|
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
|
–
|
|
|
BRENDA:
BS435198
|
|
|
|
acetoacetyl-CoA + [acyl-carrier_protein] <=> CoA + a_acetoacetyl-[acyl-carrier_protein]
|
2.3.1.85
fatty-acid synthase system
|
–
|
|
|
BRENDA:
BS455153
|
|
|
|
acetoacetyl-CoA + [acyl-carrier_protein] <=> CoA + acetoacetyl-[acyl-carrier_protein]
|
2.3.1.39
[acyl-carrier-protein] S-malonyltransferase
|
–
|
|
|
BRENDA:
BS455154
|
|
|
|
acetoacetyl-CoA + methylmalonyl-CoA <=> 3,6-dimethyl-4-hydroxy-2-pyrone + CoA + CO2 + H2O
|
2.3.1.233
1,3,6,8-tetrahydroxynaphthalene synthase
|
–
|
|
|
BRENDA:
BS429860
|
|
|
|
acetoacetyl-CoA <=> phloroglucinol + Triacetate_lactone + CO2 + CoA
|
2.3.1.253
phloroglucinol synthase
|
–
|
|
|
BRENDA:
BS439009
|
|
|
|
acetoacetyl-CoA <=> Triacetate_lactone + CoA + CO2 + H2O
|
2.3.1.233
1,3,6,8-tetrahydroxynaphthalene synthase
|
–
|
|
|
BRENDA:
BS429861
|
|
|
|
acetoacetyl-CoA + acetoacetyl-CoA + H2O <=> 3-hydroxy-3-methyl-5-oxoheptanedioyl-CoA + CoA
|
2.3.3.10
hydroxymethylglutaryl-CoA synthase
|
–
|
|
|
BRENDA:
BS321808
|
|
|
|
acetoacetyl-[acyl-carrier_protein] + acetyl-CoA <=> acetyl-[acyl-carrier_protein] + acetoacetyl-CoA
|
2.3.1.180
beta-ketoacyl-[acyl-carrier-protein] synthase III
|
–
|
|
|
BRENDA:
BS420181
|
|
|
|
acetyl-CoA + malonyl-CoA <=> acetoacetyl-CoA + CoA
|
2.3.1.41
beta-ketoacyl-[acyl-carrier-protein] synthase I
|
–
|
|
|
BRENDA:
BS387743
|
|
|
|
[acetyl-CoA_C-acetyltransferase]-S-acetyl-L-cysteine + acetyl-CoA <=> acetoacetyl-CoA + [acetyl-CoA_C-acetyltransferase]-L-cysteine
|
2.3.1.9
acetyl-CoA C-acetyltransferase
|
–
|
|
|
BRENDA:
BR52732
|
|
|
|
Octanoate + acetoacetyl-CoA <=> octanoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358848
|
|
|
|
formate + acetoacetyl-CoA <=> formyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358847
|
|
|
|
4-Pentenoate + acetoacetyl-CoA <=> 4-pentenoyl-CoA + acetoacetate
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358849
|
|
|
|
L-3-aminobutanoyl-CoA + 2-oxoglutarate <=> acetoacetyl-CoA + L-glutamate
|
2.6.1.111
3-aminobutanoyl-CoA transaminase
|
–
|
|
|
BRENDA:
BS438015
|
|
|
|
3-hydroxybutyryl-CoA + NAD+ <=> acetoacetyl-CoA + NADH
|
1.1.1.178
3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1.1.1.211
long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.212
3-oxoacyl-[acyl-carrier-protein] reductase (NADH)
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
|
–
–
–
–
|
B
|
|
BRENDA:
BS187430
|
|
|
|
acetoacetyl-CoA + NADH <=> (R)-3-hydroxybutyryl-CoA + NAD+
|
1.1.1.36
acetoacetyl-CoA reductase
|
–
|
|
|
BRENDA:
BS188082
|
|
|
|
acetoacetyl-CoA + NADH <=> (3R)-hydroxybutyryl-CoA + NAD+
|
1.1.1.36
acetoacetyl-CoA reductase
|
–
|
|
|
BRENDA:
BS369971
|
|
|
|
epsilon-Acetyl-CoA + acetoacetate <=> acetate + acetoacetyl-CoA
|
2.8.3.9
butyrate---acetoacetate CoA-transferase
|
–
|
|
|
BRENDA:
BS358823
|
|
|
|
acetoacetyl-CoA + oxaloacetate <=> 3-oxoglutaryl-CoA + pyruvate
|
2.1.3.1
methylmalonyl-CoA carboxytransferase
|
–
|
|
|
BRENDA:
BS320096
|
|
|
|
acetoacetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ <=> palmitate + (n+1)_CoA + n CO2 + 2n NADP+
|
2.3.1.85
fatty-acid synthase system
|
–
|
|
|
BRENDA:
BS455156
|
|
|
|
acetoacetyl-CoA + 3 malonyl-CoA + NADPH + H+ <=> Triacetate_lactone + CoA + NADP+
|
2.3.1.165
6-methylsalicylic-acid synthase
|
–
|
|
|
BRENDA:
BS435197
|
|
|
|
(R)-3-hydroxybutyryl-CoA + NADPH + H+ <=> acetoacetyl-CoA + NADP+
|
1.1.1.36
acetoacetyl-CoA reductase
|
–
|
B
|
|
BRENDA:
BS394976
|
|
|
|
acetoacetyl-CoA + NADPH <=> (R)-3-hydroxybutyryl-CoA + NADP+
|
1.1.1.100
3-oxoacyl-[acyl-carrier-protein] reductase
1.1.1.36
acetoacetyl-CoA reductase
|
–
–
|
|
|
BRENDA:
BS186946
|
|
|
|
acetoacetyl-CoA + 2 malonyl-CoA <=> Triacetate_lactone + CoA + CO2 + H2O
|
2.3.1.233
1,3,6,8-tetrahydroxynaphthalene synthase
|
–
|
|
|
BRENDA:
BS429859
|
|
|
|
acetoacetyl-CoA + malonyl-CoA <=> Triacetate_lactone + CoA
|
2.3.1.165
6-methylsalicylic-acid synthase
|
–
|
|
|
BRENDA:
BS320575
|
|
|
|
2 malonyl-CoA <=> acetoacetyl-CoA + CoA + 2 CO2
|
2.3.1.194
acetoacetyl-CoA synthase
|
–
|
|
|
BRENDA:
BS407782
|
|
|
|
3-hydroxybutyryl-CoA + acceptor <=> acetoacetyl-CoA + reduced_acceptor
|
1.3.8.1
short-chain acyl-CoA dehydrogenase
|
–
|
|
|
BRENDA:
BS258803
|
|
|
|
acetoacetyl-CoA + NADPH + H+ <=> (R)-3-hydroxybutanoyl-CoA_+NADP+
|
1.1.1.36
acetoacetyl-CoA reductase
|
–
|
|
|
BRENDA:
BS451045
|
|
|
|
acetyl-3''-dephospho-CoA + acetoacetyl-CoA + H2O <=> 3-hydroxy-3-methylglutaryl-CoA + 3''-dephospho-CoA
|
2.3.3.10
hydroxymethylglutaryl-CoA synthase
|
–
|
|
|
BRENDA:
BS321801
|
|
|
|
acetyl_pantetheine + acetoacetyl-CoA + H2O <=> 3-hydroxy-3-methylglutaryl-CoA + pantetheine
|
2.3.3.10
hydroxymethylglutaryl-CoA synthase
|
–
|
|
|
BRENDA:
BS321802
|
|
|
|
L-3-aminobutanoyl-CoA + pyruvate <=> acetoacetyl-CoA + L-alanine
|
2.6.1.111
3-aminobutanoyl-CoA transaminase
|
–
|
|
|
BRENDA:
BS438016
|
|
|
|
CoA + 3-oxohexanoyl-CoA <=> acetyl-CoA + acetoacetyl-CoA
|
2.3.1.16
acetyl-CoA C-acyltransferase
|
–
|
|
|
SABIO-RK:
12914
|
|